TARDBP and depressive disorder: Symptoms such as apathy in patients with FTLD-Other pathology and psychosis in FTLD-TDP-43 and PSP pathological groups magnified 3 years post-baseline assessment, while depression in those with CBD pathologies accentuated within 2 years post-baseline.84 All other FTLD pathologies were found to be present across a range of clinical diagnoses,87 including AD and PPA.