PICK1 and Alzheimer disease: Turning to pathology, we found evidence for spatial clustering of pathological groups significantly differently from the null in AD pathology, corticobasal degeneration (CBD), FTLD-Tau, LBD, PSP pathology (all P < 0.001), FTLD-Pick (P = 0.019), FTLD-Tar DNA binding protein-43 (TDP-43; P = 0.002) and Other pathological groups (P = 0.015) (Fig. 4).