These groups displayed non-random, local spatial clustering patterns (Fig. 5A and B); however, we found no clear one-to-one mapping between clinical and pathological labels, with the exception of pathological PSP label (corresponding largely to FTLD-motor clinical label) and FTLD-Pick pathology (corresponding to either bvFTD or PPA clinical groups). This evidence concerns the gene PICK1 and supranuclear palsy, progressive, 1.