Although the exact cause of AD is unknown, several mechanisms are believed to be involved, including increased inflammation, ROS accumulation, deposition of amyloid-beta protein, cholinergic insufficiency, tau protein neurofibrillary tangles (NFTs), metal ion dynamic equilibrium problem, and a shortage of neurotropic agents (Ferri et al. 2005; Macauley and Holtzman 2015). The gene discussed is MAPT; the disease is Alzheimer disease.