It is known that cyclooxygenase 2 (COX-2) is a crucial enzyme in inflammation and prostaglandin formation which is constitutively produced in neurons (Samad et al. 2001; Tyagi et al. 2020) and increased in AD patients (Hoozemans et al. 2004; Hoozemans and O'Banion 2005). Here, PTGS2 is linked to Alzheimer disease.