Regarding the hypothalamic-pituitary–gonadal axis, central precocious puberty was observed in three girls (20%—two patients were treated with Gonadotropin Releasing Hormone [GnRH] analogues), polycystic ovary syndrome in three women (20%), ovarian failure in one woman (7%) and testicular failure in one boy (4%) without further etiological data. This evidence concerns the gene GNRH1 and ovarian dysfunction.