We only observed a significant effect of neutralizing anti-IFNα2 autoAbs on the subsequent development of severe COVID-19 leading to hospitalization (P = 0.03311; Fig. 3 A and Table S2), and not on any of the other recorded outcomes which, for HIV-1 at least, might reflect the high effectiveness of long-term antiretroviral therapy. Here, IFNA2 is linked to COVID-19.