BTG3 and infection: Given the apparent severe consequences of anti-IFN-I autoAbs for infection susceptibility (reviewed in Bastard et al. [2024a]; Hale [2023]), in the future there may be a clear clinical role for performing diagnostic autoimmune (e.g., ANA test and others) or TREC quantifications to help predict an individual’s risk of developing this form of IFN system deficiency.