The resulting statistical model, which included CDH2, FAP, and LDL variables, achieved an optimal diagnostic performance of AUC of 0.91 (95% CI: 0.75–0.97) with a sensitivity of 100% and specificity of 84%, underlying the relevance of the combination of novel parameters to establish the future blood surrogates’ indexes with the most reliable parameters for the minimally invasive diagnosis of steatosis in MASLD, clinical management and prognosis. The gene discussed is CDH2; the disease is steatosis.