Both missing variants: ARID1A:p.Gln563Ter and TP53:p.Ser261ValfsTer84 were not present in the ClinVar database, but they would be classified in clinical routine practice as likely oncogenic/oncogenic based on the “Standards for the classification of pathogenicity of somatic variants in cancer” recently published as joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC) [25]. The gene discussed is TP53; the disease is cancer.