MEST and Infertility: Unlike significant hypermethylation of CEP41 and GNASAS in infertile males, we did not find statistically significant methylation differences of MEST, MESTIT1, IGF2AS, and H19. Marques et al. [50] detected aberrant methylation of H19 and MEST in sperm from oligozoospermic patients; however, they did not include a fertile group for comparison.