GLP‐1 agonists already used in obesity treatment, semaglutide and liraglutide, are engineered with fatty‐acid acylation to prevent degradation by oligomer forming, with semaglutide additionally undergoing N‐terminal modification to further inhibit DPP‐4 proteolysis.27 This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.