NF1 and neoplasm: Additionally, the selectivity of Y102 for NF1-deficient yeast cells is recapitulated in an isogenic pair of NF1-deficient cell lines, as well as matched tumor and normal Schwann cell lines from an individual with NF1, demonstrating preferential sensitivity in cells that lack both copies of the NF1 gene compared to wild-type or NF1 heterozygous cells.