SOCS are a group of proteins known to negatively regulate cytokine signaling. SOCS have also been found to inhibit effector T cell responses during MTB infection as well as contribute to resistance to IFNγ‐mediated mycobactericidal activity in human macrophages (Srivastava et al., 2011; Vázquez et al., 2006). However, SOCS4 in particular has been found to play a host‐protective role in trafficking of CD8 T cells and activation of T cell receptors during influenza infection (Kedzierski et al., 2014). This evidence concerns the gene CD8A and influenza.