F5 and thrombophilia: In women with factor V Leiden, the risk of VTE significantly rises by 30-fold in heterozygous individuals and 100-fold in homozygous individuals when combined with oral contraceptive pills [9]. Testing for thrombophilia conditions in patients diagnosed with the first episode of DVT/PE is being discouraged according to the American Society of Hematology (ASH) guidelines as it is expensive with no clinically meaningful benefit.