Hyperuricemia also occurs due to decreased action of mutated HGPRT that changes hypoxanthine to inosine monophosphate (IMP) and guanosine to guanosine monophosphate (GMP); these disorders are called Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome, respectively [5,6]. This evidence concerns the gene HPRT1 and hyperuricemia.