ACE: angiotensin converting enzyme; FBC: full blood count; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; ANA: anti-nuclear antibodies; RF: rheumatoid factor; HLA: human leukocyte antigen; VDRL: venereal disease research laboratory; RPR: rapid plasma reagin; MRI: magnetic resonance imaging; CT: computed tomography; TBC: tuberculosis; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; AI: artificial intelligence. The gene discussed is ACE; the disease is systemic lupus erythematosus.