Similar to TnI, TnT levels have been shown to be associated with lower LVEF, higher rates of arrhythmias and reduced long-term survival.[12,23] One study evaluating 12 patients with SSc cardiac showed that TnT demonstrated greater correlation with cardiac involvement in SSc compared to NT-proBNP, and had superior diagnostic accuracy in cardiac dysfunction.[24]. This evidence concerns the gene NPPB and systemic sclerosis.