Levels of GDF-15 are increased in the sera of SSc patients and are associated with worse outcomes in interstitial lung disease and pulmonary arterial hypertension.[47] GDF-15 positively correlated with extracellular volume and native T1 mapping on cMRI[48] and left ventricular dysfunction on echocardiography.[49]. The gene discussed is GDF15; the disease is interstitial lung disease.