In addition, CD3 on CD39+ CD8+ T cell (OR = 0.884, 95%CI 0.782–1.000, p = 0.049, PFDR = 0.049) reduced the risk of SS, and the results of the other four methods were similar: MR-Egger (OR = 0.874, 95%CI 0.645–1.185, p = 0.402), weighted median (OR = 0.894, 95%CI 0.750–1.065, p = 0.208), simple mode (OR = 0.953, 95%CI 0.752–1.208, p = 0.699), and weighted mode (OR = 0.886, 95%CI 0.736–1.066, p = 0.220). The gene discussed is ENTPD1; the disease is synovial sarcoma.