CD27 on IgD+ CD24+ B cell (OR = 1.115, 95%CI 1.044–1.191, p = 0.001, PFDR = 0.027) also increased the risk of SS, and the results of the other four methods were similar: MR-Egger (OR = 1.153, 95%CI 1.053–1.262, p = 0.004), weighted median (OR = 1.151, 95%CI 1.041–1.271, p = 0.006), simple mode (OR = 1.005,95%CI 0.839–1.204, p = 0.958), and weighted mode (OR = 1.167,95%CI 1.064–1.280, p = 0.003). Here, CD27 is linked to synovial sarcoma.