Ma et al. (2022) finally screened the pivotal genes related to TNBC prognosis and immunity, while we finally screened the cell death characteristic genes related to mitochondrial function in early breast cancer. Moreover, we speculate that CREB3L1, CAPG, SPINT1 and GRK3 may participate in the process of breast cancer through vasopressin regulated water reabsorption, circumferential rhithm mmal, and o glycan biosynthesis pathways (Figure 11). The gene discussed is GRK3; the disease is breast carcinoma.