SOX2 and glioblastoma: In addition, PVT1 regulates E74-like factor 4 (ELF4) expression by competitively binding to miR-365 and controls the stemness of GSCs via the miR-365/ELF4/SOX2 axis (Gong et al., 2021) Thus, PVT1 may serve as a potential therapeutic target and prognostic indicator in glioblastoma.