Aberrant expression patterns of drug transporters such as P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), dysregulation of DNA repair process, cancer stem cells, resistance to cell death, and recently transcriptional disruption of miRNA are regarded as the most primary methods for development of chemotherapy-resistant cancer cell [4, 5]. This evidence concerns the gene ABCB1 and cancer.