Metabolites derived from glutamine metabolism, for instance, can promote T cell-driven immunosuppressive programs (51).In breast cancer patients, the increased expression of some GPI-anchored inhibitory receptors on the surface of CD8+ T cells during T cell exhaustion may be related to cellular responses to changes in the TME, leading to metabolic reprogramming and potentially promoting increased GPI-anchored protein biosynthesis. The gene discussed is CD8A; the disease is breast cancer.