With the further establishment of BC prediction models for GPI-anchored biosynthesis-related genes, the role of GPAA1 and PIGU are pivotal in T cell exhaustion diagnosis and patient prognosis, suggesting the potential utility of GPI-anchored biosynthesis related genes as biomarkers for diagnosing T cell depletion status and predicting prognosis in BC patients. Here, GPAA1 is linked to breast cancer.