Exosomes prepared from ovalbumin (OVA)‐pulsed, activated DC were modified with anti‐CTLA‐4 antibody (EXO–OVA–mAb), which increased the migration of CD4 and CD8 T cells to the tumor site and increased the ratio of CTLs/Tregs in the microenvironment of the B16 melanoma tumor model.364. Here, CTLA4 is linked to neoplasm.