CD274 and neoplasm: (16, 17)emphasize the concept of “immunogram” which combines several parameters (e.g., mutational burden – tumor foreignness, general immune status – lymphocyte count, immune cell infiltration – intratumoral T cells, absence of checkpoints – PD-L1, absence of soluble inhibitors – Il-6, absence of inhibitory tumor metabolisms – LDH, glucose utilization, tumor sensitivity to immune effectors – MHC expression etc.)to estimate the efficacy of immunologic treatments.