CD163 and cancer: Lastly, CD163 is an acute phase-regulated receptor involved in protecting tissues from free hemoglobin-mediated oxidative damage (63) (Uniprot: Q86VB7), and MTSS2 (MTSS I-BAR domain containing 2, Uniprot: Q765P7) is related to tumor metastasis and cancer progression via interactions with the actin cytoskeleton, and belongs to the MTSS family (64).