CD8A and neoplasm: Attributes of the melanoma sample could enhance the prediction of the immunotherapy response, such as; proteins related to antigen presentation (4–6), tumor mutation burden (7–9), CD8 protein in T-cells (10), the presence of tumor-infiltrating lymph cells (11, 12), the composition of the tumor microenvironment (TME) (13, 14), expression of self-antigens (15).