Chest CT performed at the same time (in December 2021) detected a left upper lobe mass (2.3x1.6cm) with multiple, small bilateral pulmonary nodules, and a needle biopsy of left upper lobe lesion confirmed well-differentiated adenocarcinoma, with EGFR (+), P63 (-), Ki-67 10%+, CK7 (+), p53 weak, Napsin A (+), TTF-1 (+), ALK (-). This evidence concerns the gene TP53 and adenocarcinoma.