ESR1 and breast cancer: Figures 4A–J shows the regression coefficients of different prognostic factors in different l. For example, Figure 4G shows βER(l) (solid black line), with breast cancer deaths occurring an average of 0.25 years later (y-axis βER(4.5)≈−0.25) in ER-positive patients than in ER-negative patients during the 4.5-year follow-up (x-axis l = 4.5); breast cancer deaths occurring an average of 0.42 years later (y-axis βER(6.5)≈−0.42) in ER-positive patients than in ER-negative patients during the 6.5 years (x-axis l=6.5).