In the inflammatory response of CRS, related inflammatory cytokines can reduce the expression of the TREK-1 potassium channel, while blocking the TREK-1 channel can further promote inflammatory cytokine-induced nasal mucosal epithelial permeability and lymphocyte trans-endothelial infiltration (Kim et al., 2018). The gene discussed is KCNK2; the disease is congenital rubella syndrome.