Therecent studies revealed that BK/TREK-1 potassium channel play a protective role in the nasal mucosal function through p38-MAPK pathway, and KCa3.1/Kv1.3 enhance the inflammatory response of CRS by regulating immune cell function, intracellular Ca2+ signaling and ERK/MAPK/NF-κB pathway. The gene discussed is KCNA3; the disease is congenital rubella syndrome.