Twenty-three immunophenotypes were identified to be significantly associated with Hodgkin lymphoma risk through the IVW approach, and the odds ratio values of CD64 on CD14− CD16+ monocyte [2.31, 95% confidence interval (CI) = 1.41–3.79, P1 = 0.001], IgD+ CD24+ B-cell %lymphocyte (2.06, 95% CI = 1.13–3.79, P1 = 0.018), B-cell %lymphocyte (1.94, 95% CI = 1.08–3.50, P1 = 0.027), CD24+ CD27+ B-cell %lymphocyte (1.68, 95% CI = 1.03–2.74, P1 = 0.039), and CD14+ CD16− monocyte %monocyte (1.60, 95% CI = 1.15–2.24, P1 = 0.006) ranked in the top five. The gene discussed is CD27; the disease is Hodgkins lymphoma.