Individuals with CD86 on granulocyte, CD28-CD8+ T-cell Absolute Count, CCR2 on myeloid dendritic cell, CD3 on effector memory CD8+ T cell, and NKT %lymphocyte will have a 2.35×, 1.76×, 1.30×, 1.29×, and 1.28× increased risk of developing NHL compared to those without those immunophenotypes, respectively. The gene discussed is CD28; the disease is non-Hodgkin lymphoma.