TTR and heart failure: Cardiomyopathy is a common manifestation of ATTR amyloidosis, in which patients may develop symptoms of heart failure (HF) and experience a particularly poor life expectancy after diagnosis 3 ATTR cardiomyopathy (ATTR-CM) can be acquired through aggregation of wild-type TTR (ATTRwt) or inherited from a variety of genetic variants of TTR (ATTRv) .4