A stronger positive correlation between METS-IR and pulse wave velocity (PWV) was observed in individuals with high cardiovascular risk conditions after adjusting for sex, age, treatment for hypertension, and smoking status (β=0.350, 95% CI: 0.204–0.418), compared to other non-insulin-based IR indices such as the TG/HDL-C index and the TyG index (20). The gene discussed is INS; the disease is Hypertension.