On the other hand, predictive biomarkers derived from transcriptomic data include tumor oncogene expression signatures, such as genes related to MYC (8), WNT/β-catenin (9, 10), or RAS (11) signaling; gene expression profiles within the tumor immune microenvironment (TIME), such as IFNγ-responsive genes (12), chemokines (13, 14), MHC classes I and II (15); and cytotoxic T-cell and effector T-cell (16, 17) gene expression markers that have been reported to be predictive of ICI response in metastatic melanoma. Here, HLA-C is linked to neoplasm.