Additionally, several Dox_H3K27ac-upregulated genes including Egr-1, Adam17, Dusp6, Ddit4 and Angptl4 might potentially contribute to Dox-induced cardiotoxicity (Fig. 6E), since they have been proved to be associated with the progression of cardiovascular disease [34–42]. The gene discussed is EGR1; the disease is cardiovascular disorder.