In cases without diabetes mellitus (n = 22) a significant negative correlation was observed between insulin resistance expressed as the HOMA-R (mmol·μIU/ml; r = -0.586, p = 0.004) and the fasting insulin levels (μIU/L; r =-0.650, p < 0.001) on the one hand and the serum SHBG levels (nmol/L) on the other. This evidence concerns the gene INS and Insulin resistance.