The result shows that the 1-stearoyl-GPI (18:0) levels were found to mediate CD45 on HLA DR+ T cell on Diabetic nephropathy and The N-acetyl-isoputreanine levels were found to mediate CD16−CD56 on HLA DR+ NK on DN (Figs. 7, 8). The gene discussed is PTPRC; the disease is diabetic kidney disease.