According to this study, the CD33dim HLA DR+ CD11b+ AC (Myeloid cell Panel), CD16−CD56 on HLA DR+ NK cell (TBNK Panel) and CD45 on HLA DR+ T cell (TBNK Panel) among four immune traits (MFI, RC, AC, and MP) have significant causal effects on DN (FDR < 0.05), which is important in exploring the pathogenesis of DN. This evidence concerns the gene PTPRC and liver dysplastic nodule.