The main reason may be that glucose-induced advanced glycation end-products react with specific cell surface receptors, resulting in neurodegeneration and arteriosclerosis, while the harm of anaesthesia exacerbates the vulnerability of diabetic patients to such neuropathological changes, leading to a greater impact of anaesthesia on cognitive function than in nondiabetic patients (Brownlee 2001). This evidence concerns the gene CD177 and arteriosclerosis disorder.