For induction of apoptosis in leukemia, dimethyl fumarate suppresses the NF-κB axis; notably, this compound suppresses both canonical and non-canonical pathways of NF-κB in MT-2 cells, while it only suppresses the non-canonical pathway of NF-κB to induce apoptosis in MT-1 cells [125]. The gene discussed is NFKB1; the disease is leukemia.