The histopathological characteristics of four adult HGGs (patients #9-#12) with SPECC1L::NTRK2, FKBP15::NTRK2, KANK1::NTRK2, and BCR::NTRK2 fusions and a paediatric HGG with the ZBTB43::NTRK2 fusion (patient #7, 2 y/F) were consistent with IDH wild-type (IDH-wt) GBM. Here, NTRK2 is linked to glioblastoma.