MKI67 and neoplasm: In this study, we detected the expression of Ki-67 in tumor tissues of tumor bearing mice treated with various drugs and the results are shown in Fig. 8g, the expression of Ki-67 was the most significant in the saline treatment group, followed by Cur, PPH@C, Cur + Rg3 and PPH@CR group, among which the PPH@CR group had the least expression of Ki-67, indicating that the tumor cells of tumor-bearing mice after PPH@CR treatment had the weakest proliferation ability.