In addition, in vitro cell experiments and in vivo experiments in tumor-bearing mice have shown that PPH@CR can promote the maturation of DCs and the proliferation of CD4+ T cells and CD8+ T cells by inducing ICD in tumor cells, so that the tumor microenvironment of relatively “cold” TNBCs can be transformed into a “hot” tumor microenvironment infiltrated by immune cells. Here, CD8A is linked to neoplasm.