As shown in Fig. 8h, the expression of CD44 in tumor tissue from most to least was as follows: saline, Cur, PPH@C, Cur + Rg3 and PPH@CR group, and among which the CD44 expression of tumor tissue in the PPH@CR group was the least and significantly lower than that in the other groups, indicating that PPH@CR had the strongest ability to reduce stem cells in tumor tissues, which helps to reduce tumor recurrence and resistance to treatment. This evidence concerns the gene CD44 and neoplasm.