Obesity and saturated fat exposure is known to stimulate NF-κB transcriptional activity and the secretion of pro-inflammatory mediators in peripheral organs, such as liver, white adipose tissue, and leukocytes [44], In the brain, the neuroinflammatory process in DIO remains unclear, and somehow controversial. This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.