To evaluate whether the established cell models could represent the biology of tumors from carriers of the BUB1B in-frame variant c.1171_1173del, we performed RNA sequencing in tumor/normal matched prostate tissues from patient HPC63, carrying the germline variant c.1171_1173del, as well as in prostate tissues from patient HPC278, carrying the frameshift variant c.2481del, and from three additional HPC patients negative for known BUB1B germline variants. The gene discussed is BUB1B; the disease is neoplasm.