Hahn et al. (2016), in an attempt to clarify the phenotypic implications of two BUB1B variants (c.1171_1173del and c.2834G > A) identified in the germline of early-onset colorectal cancer cases, have induced overexpression of both mutants and WT BUB1B in HEK293 and HeLa cells and found no differences in protein expression, localization (at KTs), or Bub3 binding between the three cell models [8]. Here, BUB3 is linked to colorectal cancer.