When comparing the expression in lung fibroblasts from healthy subjects and COPD patients there was a higher expression of ATF6 (p = 0.037, Fig. 2c) and a lower expression of SOD3 (p = 0.016, Fig. 2d) and c-Jun (p = 0.039, Fig. 2e) in COPD patients at hypoxic conditions. The gene discussed is ATF6; the disease is chronic obstructive pulmonary disease.