FMO5 and Constipation: Currently, numerous studies have confirmed that elevated levels of oxidative stress are observed in patients with constipation and animal models, suggesting a potential link between constipation and oxidative stress [5], which may be related to the elevation of NADPH oxidase in patients with chronic constipation and the fact that oxidative stress can further affect intestinal neurons [6, 7].The oxidative balance score (OBS) serves as a metric for antioxidant and pro-oxidant exposure in diet and lifestyle, reflecting overall oxidative stress levels [8].