AKT1 and neoplasm: Given it, the long-lived CO along with residual 1O2 and •OH was expected to fight against lung cancer with the elevated safety profile via activating Akt signaling pathway including AKT-1, HMOX-1 and NRF-2 and facilitating intracellular communication, and prolong the survival rate associated with tumor recurrence and metastasis inhibition (Fig. 1b).