MKI67 and cancer: Furthermore, upon comparing the results of the experimental group with those of MnCO/Ce6@H-MnO2 group and Ce6@H-MnO2 + US group, it is evident that Ki67, a proliferation-related protein, exhibits weak expression in the experimental group while there is a more significant expression of corresponding apoptosis-related proteins, revealing that the sequential treatment can expedite the deaths of cancer cells and oppose the replication of cancer cells.