For example, for LDL-C, the LDL-C to apolipoprotein B (apo B) ratio had been demonstrated to be independently associated with all-cause mortality and cardiovascular events in peritoneal dialysis patients [39], and The High-density lipoprotein cholesterol (HDL-C) to LDL-C ratio can be applied to early assessment of disease severity and outcome in patients with acute pancreatitis admitted to ICU [40]. The gene discussed is APOB; the disease is acute pancreatitis.