PTPRR and ependymoma: We note that most of our cases were suspected as PTPR’s prior to methylation profiling, but also note that a subset was given either a descriptive diagnosis or were suspected as an alternative tumor type (for example ependymoma, astroblastoma and medulloblastoma), highlighting the need to increase awareness of this tumor type and also the utility of methylation profiling to evaluate this uncommon tumor type.