To characterize the methylation profiles, we first utilized UMAP as a dimension reduction visualization method to study the methylation patterns of these 76 PTPR tumors with tumors in proximity, including ZFTA fusion-positive supratentorial ependymoma, and pineal parenchymal and retinal tumors (Fig. 1a, Additional file 2: Table S1). Here, PTPRR is linked to ependymoma.