Obesity not only promotes chronic systemic inflammation and oxidative stress, leading to tissue immune cell infiltration and the formation of kidney stones, but also increases adipokine expression and changes the status of inflammatory molecules, including interleukin-6 and tumor necrosis factor-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α [24, 25]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.