15% of children with IBD is VEO-IBD, and genetic sequencing techniques have identified single gene defects that commonly occur in children with VEO-IBD, including genes affecting intestinal epithelial barrier and response function, autoimmune function, excessive inflammatory response [3, 4].For example IL-10、TTC7A、FOXP3、CYBA, etc. [5]. The gene discussed is FOXP3; the disease is inflammatory bowel disease.