PTH and migraine disorder: Although several medications such as non-steroidal anti-inflammatory drugs (NSAIDs) [7], serotonin (5-HT1) receptor agonists [8], CGRP receptor antagonists, and anti-CGRP monoclonal antibodies [9, 10] have been used for the treatment of migraine and therefore might be also suitable for PTH, they are unlikely to provide efficient pain relief in TBI patients due to the complex pathophysiology of PTH.