The treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly reduced the serum level of IL-1β comparable to that in STZ-induced T1DM mice treated with sodium citrate buffer (108.77 ± 2.3 pg/ml, 34.30 ± 5.98 pg/ml and 50.60 ± 6.80 pg/ml, respectively versus 142.87 ± 6.50 pg/ml) (Fig. 4D). This evidence concerns the gene IL1B and type 1 diabetes mellitus.