Our data revealed that the administration of STZ-induced T1DM mice with sodium citrate buffer, insulin and adoptively transferred dBMCs significantly decreased the serum level of INF-γ comparing to that in naive mice received sodium citrate buffer (1.01 ± 0.11 pg/ml, 2.11 ± 0.20 pg/ml, 3.88 ± 0.11 pg/ml and 3.38 ± 0.03 pg/ml, respectively versus 3.94 ± 0.13 pg/ml) (Fig. 4A). Here, INS is linked to type 1 diabetes mellitus.