The treatment of STZ-induced T1DM mice with adoptively transferred nBMCs or adoptively transferred dBMCs significantly decreased the serum level of IL-4 comparing to that in STZ-induced T1DM mice treated with insulin (51.00 ± 1.59 pg/ml and 67.17 ± 3.67 pg/ml, respectively versus 101.37 ± 7.88 pg/ml) (Fig. 4E). Here, IL4 is linked to type 1 diabetes mellitus.