Moreover, the administration of STZ-induced T1DM mice with sodium citrate buffer, insulin and adoptively transferred dBMCs significantly increased the serum level of IL-1β comparing to that in naive mice received sodium citrate buffer (142.87 ± 6.50 pg/ml, 108.77 ± 2.38 pg/ml and 50.60 ± 6.80 pg/ml, respectively versus 21.10 ± 1.50 pg/ml) (Fig. 4D). Here, INS is linked to type 1 diabetes mellitus.