INS and type 1 diabetes mellitus: The treatment of STZ-induced T1DM mice with adoptively transferred nBMCs or adoptively transferred dBMCs significantly reduced the serum level of IL-1β comparing to that in STZ-induced T1DM mice treated with insulin (34.30 ± 5.98 pg/ml and 50.60 ± 6.80 pg/ml, respectively versus 108.77 ± 2.38 pg/ml) (Fig. 4D).