INS and type 1 diabetes mellitus: On the other hand, the administration of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly reduced the serum level of ICA comparing to that in STZ-induced T1DM mice received sodium citrate buffer (2.01 ± 0.08 pg/mg, 0.79 ± 0.01 pg/mg and 1.12 ± 0.07 pg/mg, respectively, respectively versus 3.09 ± 0.17 pg/mg) (Fig. 5A).