Furthermore, the treatment of STZ-induced T1DM mice with insulin or adoptively transferred dBMCs led to significant decrease in the total count of leucocytes comparing to that in STZ-induced T1DM mice received sodium citrate buffer (6.25 ± 0.15 × 103 and 4.45 ± 0.15 × 103, respectively versus 8.35 ± 0.35 × 103) (Fig. 9A). The gene discussed is INS; the disease is type 1 diabetes mellitus.