INS and type 1 diabetes mellitus: Furthermore, the treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly decreased the serum level of the total Ig comparing to that in naive mice received sodium citrate buffer (46.63 ± 3.01 ng/ml, 20.33 ± 1.84 ng/ml and 38.56 ± 1.60 ng/ml, respectively versus 132.30 ± 9.11 ng/ml) (Fig. 6).