INS and type 1 diabetes mellitus: Moreover, the treatment of STZ-induced T1DM mice with sodium citrate buffer, insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly increased the serum level of IL-4 comparing to that in naive mice received sodium citrate buffer (181.47 ± 2.54 pg/ml, 101.37 ± 7.88 pg/ml, 51.00 ± 1.59 pg/ml and 67.17 ± 3.67 pg/ml respectively versus 38.60 ± 3.85 pg/ml) (Fig. 4E).