The current data indicated that the treatment of STZ-induced T1DM mice with sodium citrate buffer, insulin and adoptively transferred dBMCs significantly elevated the level of Islet cell autoantibodies (ICA) comparing to that in naive mice received sodium citrate buffer (3.09 ± 0.17 pg/mg, 2.01 ± 0.08 pg/mg and 1.12 ± 0.07 pg/mg, respectively versus 0.75 ± 0.0.09 pg/mg) (Fig. 5A). The gene discussed is INS; the disease is type 1 diabetes mellitus.