The treatment of STZ-induced T1DM mice with adoptively transferred nBMCs significantly decreased the serum level of the total Ig comparing to that in STZ-induced T1DM mice treated with insulin (20.33 ± 1.84 ng/ml versus 46.63 ± 3.01 ng/ml) (Fig. 6). The gene discussed is INS; the disease is type 1 diabetes mellitus.