INS and type 1 diabetes mellitus: Our results showed that the treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly reduced the level of serum IL-4 comparing to that in STZ-induced T1DM mice received sodium citrate buffer (101.37 ± 7.88 pg/ml, 51.00 ± 1.59 pg/ml and 67.17 ± 3.67 pg/ml, respectively versus 181.47 ± 2.54 pg/ml) (Fig. 4E).