INS and type 1 diabetes mellitus: Additionally, the treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs resulted in significant elevation in the level of A-2 comparing to that in STZ-induced T1DM mice received sodium citrate buffer (0.42 ± 0.01 pg/mg, 0.84 ± 0.01 pg/mg and 0.57 ± 0.01 pg/mg, respectively versus 0.12 ± 0.01 pg/mg) (Fig. 5E).