INS and type 1 diabetes mellitus: The treatment of STZ-induced T1DM mice with adoptively transferred nBMCs or adoptively transferred dBMCs significantly decreased the serum level of TGF-β comparing to that in STZ-induced T1DM mice treated with insulin (32.53 ± 2.00 pg/ml and 27.96 ± 2.40 pg/ml, respectively versus 99.47 ± 3.98 pg/ml) (Fig. 4C).