Additionally, the treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs resulted in significant decrease in the level of IAA, comparing to that in STZ-induced T1DM mice received sodium citrate buffer (22.20 ± 1.40 pg/mg, 11.20 ± 90 pg/mg and 14.67 ± 80 pg/mg, respectively, respectively versus 61.07 ± 1.88 pg/mg) (Fig. 5B). The gene discussed is INS; the disease is type 1 diabetes mellitus.