However, the treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs or adoptively transferred dBMCs led to significant decrease in the level of serum creatinine comparing to that in STZ-induced T1DM mice received sodium citrate buffer (Fig. 8C), while the treatment of STZ-induced T1DM mice with adoptively transferred dBMCs result in significant increase in the level of serum creatinine comparing to that in STZ-induced T1DM mice administrated insulin (Fig. 8C). This evidence concerns the gene INS and type 1 diabetes mellitus.