Furthermore, the injection of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly decreased the serum level of TNF-α comparing to that in STZ-induced T1DM mice received sodium citrate buffer (73.50 ± 5.42 pg/ml, 28.73 ± 1.61 pg/ml and 58.80 ± 4.06 pg/ml, respectively versus 130.47 ± 2.21 pg/ml) (Fig. 4B). This evidence concerns the gene INS and type 1 diabetes mellitus.