INS and type 1 diabetes mellitus: On the other hand, treatment of STZ-induced T1DM mice with insulin and adoptively transferred nBMCs significantly decreased the percentage of serum HbA1C comparing to that in STZ-induced T1DM mice received sodium citrate buffer alone (4.30 ± 0.10 and 4.50 ± 0.05%, respectively versus 5.25 ± 0.15%), while the treatment of STZ-induced T1DM mice with adoptively transferred dBMCs significantly increased the level of serum HbA1C% comparing to that in STZ-induced T1DM mice received insulin (4.9 ± 0.05 versus 4.30 ± 0.10%) (Fig. 2C).