Moreover, the administration of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly decreased the serum level of TGF-β comparing to that in STZ-induced T1DM mice received sodium citrate buffer (99.47 ± 3.98 pg/ml, 32.53 ± 2.00 pg/ml and 27.96 ± 2.40 pg/ml, respectively versus 146.67 ± 9.56 pg/ml) (Fig. 4C). This evidence concerns the gene TGFB1 and type 1 diabetes mellitus.