Furthermore, the treatment of STZ-induced T1DM mice with sodium citrate buffer, insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly decreased the level of serum IL-10 comparing to that in naive mice received sodium citrate buffer (59.00 ± 1.39 pg/ml, 152.33 ± 5.05 pg/ml, 223.13 ± 6.75 pg/ml and 183.93 ± 7.34 pg/ml, respectively versus 262.57 ± 5.15 pg/ml) (Fig. 4G). The gene discussed is INS; the disease is type 1 diabetes mellitus.