The administration of STZ-induced T1DM mice with adoptively transferred nBMCs and adoptively transferred dBMCs significantly decreased the serum level of INF-γ comparing to that in STZ-induced T1DM mice treated with insulin (3.88 ± 0.11 pg/ml and 3.38 ± 0.06 pg/ml, respectively versus 2.13 ± 0.35 pg/ml) (Fig. 4A). The gene discussed is INS; the disease is type 1 diabetes mellitus.