INS and type 1 diabetes mellitus: The current study revealed that administration of STZ-induced T1DM mice with sodium citrate buffer, insulin and adoptively transferred dBMCs noticeably decreased the total number of splenocytes raised the number of splenocytes comparing to naïve mice received sodium citrate buffer (4.70 ± 0.40 × 106, 6.70 ± 0.40 × 106 and 4.70 ± 0.40 × 106, respectively versus 8.60 ± 0.30 × 106) (Fig. 3).