The administration of STZ-induced T1DM mice with sodium citrate buffer significantly increased the serum level of the total immunoglobulin (Ig), while their administration with insulin or adoptively transferred dBMCs significantly decreased the serum level of total Ig comparing to that in STZ-induced T1DM mice received sodium citrate buffer (132.33 ± 5.25 ng/ml, 46.63 ± 3.01 ng/ml and 38.56 ± 1.60 ng/ml, respectively versus 24.77 ± 2.72 ng/ml) (Fig. 6). Here, INS is linked to type 1 diabetes mellitus.