On the other hand, the treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs significantly increased the serum level of INF-γ comparing to that in STZ-induced T1DM mice received sodium citrate buffer (2.11 ± 0.20 pg/ml, 3.88 ± 0.11 pg/ml and 3.38 ± 0.06 pg/ml, respectively versus 1.02 ± 0.11 pg/ml) (Fig. 4A). This evidence concerns the gene INS and type 1 diabetes mellitus.