The treatment of STZ-induced T1DM mice with insulin, adoptively transferred nBMCs and adoptively transferred dBMCs markedly increased the serum level of IL-10 comparing to that in STZ-induced T1DM mice received sodium citrate buffer (152.33 ± 5.05 pg/ml, 223.13 ± 6.75 pg/ml and 183.93 ± 7.34 pg/ml, respectively versus 59.00 ± 1.39 pg/ml) (Fig. 4G). This evidence concerns the gene IL10 and type 1 diabetes mellitus.