INS and type 1 diabetes mellitus: Additionally, the treatment of STZ-induced T1DM mice with insulin and adoptively transferred nBMCs resulted in significant decrease in the level of serum MDA comparing to that in STZ-induced T1DM mice received sodium citrate buffer (11.00 ± 0.40 nmol/ml and 13.1 ± 0.40 nmol/ml, respectively versus 37.10 ± 1.10 nmol/ml) (Fig. 7A).