The current data showed that the administration of STZ-induced T1DM mice with sodium citrate buffer, insulin and adoptively transferred nBMCs significantly increased the total count of leucocytes comparing to that in naive mice received sodium citrate buffer (8.35 ± 0.35 × 103, 6.25 ± 0.15 × 103and 8.15 ± 0.25 × 103, respectively versus 4.35 ± 0.05 × 103) (Fig. 9A). Here, INS is linked to type 1 diabetes mellitus.