Dementia progression over time was highly correlated with A + T− classification compared to A − T+ modality (ADAS‐13, p < 0.0001; ADNI‐MEM, p = 0.0032; MMSE, p = 0.0006, Figure 2G–I), indicating Aβ‐PET was indeed an independent reliable predictor of cognitive decline when comparing to tau pathology. Here, MAPT is linked to dementia.