We identified GPC2-related DEGs by separating the gene expression matrix into GPC2High and GPC2Low groups and further KEGG functional enrichment analysis revealed that these GPC2-related DEGs were particularly enriched in PI3K/AKT pathway, which attracted our attention due to its vital role in prostate carcinogenesis and progression(.Chen et al. 2016). This evidence concerns the gene AKT1 and male reproductive organ cancer.