AKT1 and cancer: Then, the activated AKT proteins were translocated into cytoplasm and nucleus, and leading to the activation of downstream targets that participated in regulating cancer survival, angiogenesis, and metastasis(.Alzahrani 2019; Chen, Zhou, Wu, Li, Wen, Sha and Wen 2016, He et al. 2021; Karar and Maity 2011; Yang et al. 2019).