KITLG and acute myeloid leukemia: In order to screen for AML-specific vulnerabilities within the family of SCF complexes, we first generated a focused CRISPR/Cas9-based knockout library covering all 72 human genes coding for F-box proteins (sgRNA sequences derived from the genome-scale CRISPR Knock-Out library GeCKOv2 [10]), together with positive and negative controls.