Notably, the effects of FBXL6 loss were stronger in the two FLT3-ITD mutated AML cell lines MOLM-13 and MV4-11 as compared to the DNMT3A and NMP1 mutated OCI-AML3 line (Fig. 1B–E, Supplementary Fig. 1A), potentially pointing towards a more specific dependency. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.