CRP and Cowden syndrome 1: In this large national registry analysis, we demonstrate that baseline inflammation, as indicated by CRP levels upon admission in ICU/ICCU, offers valuable prognostic insights for patients admitted with CS. Patients presenting with highest levels of CRP, particularly in the Q4 with CRP exceeding 68 mg/L, exhibited a 2.2 folds increase in 1-month mortality, (95% CI 1.23–3.97, p < 0.01) and a 2.14 folds increase in 1-year mortality (95% CI 1.43–3.22, < 0.01) compared to patients with lower levels of CRP on admission (as briefly summarized in supplementary Fig. 2).